Understanding the role of specific bacteria in gum disease and inflammation
Official title: Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory Diseases
Funded at Ada Forsyth Institute, INC. · NIH-11003347 · Data updated 2026-11-12
This study is looking at a special group of bacteria in your mouth called Saccharibacteria to see how they interact with other bacteria and affect gum health, especially for people dealing with periodontal disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $478,087 |
| NIH project number | 5R01DE031274-04 |
| Project ID | NIH-11003347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from periodontal disease or those at risk of developing inflammatory oral conditions.
✕Less likely to help
Patients without periodontal disease or those who do not have any inflammatory oral conditions may not benefit from this research.
What this research studies
This research investigates the role of a unique group of bacteria known as Saccharibacteria and their interactions with other bacteria in the mouth, particularly in relation to periodontal disease, which is a common infection affecting gum health. By using advanced sequencing techniques, the study aims to uncover how these bacteria contribute to inflammation and disease processes. The research involves laboratory cultivation and animal models to explore the effects of these bacteria on oral health, providing insights into their biological functions and potential impacts on human health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating periodontal disease and related inflammatory conditions.
How similar studies have gone: Previous research has shown promise in understanding the role of oral bacteria in health and disease, but the specific focus on Saccharibacteria is relatively novel.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Bor, Batbileg — Ada Forsyth Institute, INC.
- Study coordinator: Bor, Batbileg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.