Understanding the role of special RNA molecules in biological processes
Official title: Biogenesis and function of cyclic phosphate-containing RNAs
Funded at Thomas Jefferson University · NIH-11012012 · Data updated 2026-11-12
This study is looking at special tiny RNA molecules that are usually missed in regular tests, to understand how they help our cells work and respond to stress, which could lead to new insights that might improve health for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 8, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $429,000 |
| NIH project number | 1R35GM156496-01 |
| Project ID | NIH-11012012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related health issues or disorders linked to cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to RNA function or those not experiencing age-related changes may not benefit from this research.
What this research studies
This research investigates short non-coding RNAs (sncRNAs), particularly those with unique structures that are often overlooked in standard analyses. The focus is on cyclic phosphate-containing RNAs (cP-RNAs), which are important for various biological functions but are typically excluded from traditional RNA sequencing methods. By developing new techniques to identify and analyze these cP-RNAs, the research aims to uncover their roles in cellular processes and stress responses. Patients may benefit from insights gained into how these RNA molecules contribute to health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new understanding of RNA functions that may improve treatments for age-related diseases and other conditions.
How similar studies have gone: While the study of cP-RNAs is relatively novel, previous research on other types of sncRNAs has shown promising results in understanding their biological roles.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Kirino, Yohei — Thomas Jefferson University
- Study coordinator: Kirino, Yohei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.