Understanding the role of small proteins in early vertebrate development
Opening small packages: unraveling roles for microproteins during early vertebrate development
This study is looking at tiny proteins called microproteins to see how they help zebrafish grow and develop properly, which could help us understand how problems with these proteins might lead to birth defects or diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11063217 on NIH RePORTER |
What this research studies
This research investigates how small proteins, known as microproteins, influence critical processes during the early development of vertebrates, particularly focusing on zebrafish as a model organism. The study aims to uncover the functions of these microproteins in cell division, signaling, and differentiation, which are essential for normal development and preventing birth defects. By utilizing advanced techniques like ribosome profiling and mass spectrometry, the researchers will analyze the expression and roles of various microproteins during development. This could lead to a better understanding of how disruptions in these proteins can lead to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of birth defects or developmental disorders.
Not a fit: Patients with fully developed conditions unrelated to early vertebrate development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing birth defects and improving developmental health outcomes.
How similar studies have performed: While the investigation of microproteins is a relatively novel area, preliminary studies have shown promising results in understanding their roles in development.
Where this research is happening
Kansas City, United States
- Stowers Institute for Medical Research — Kansas City, United States (Active)
Researchers
- Principal investigator: Treichel, Anthony J — Stowers Institute for Medical Research
- Study coordinator: Treichel, Anthony J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.