Understanding the role of serotonin in gut and brain health
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain
This study is looking at how serotonin affects gut movement and the nervous system in people with digestive issues and mood disorders, hoping to find new ways to help those who don’t have many treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10813119 on NIH RePORTER |
What this research studies
This research investigates how serotonin, a key neurotransmitter, influences gastrointestinal (GI) motility and the development of the enteric nervous system, particularly in patients with functional gastrointestinal disorders (FGIDs) and co-occurring mood disorders. By exploring the genetic factors that may affect serotonin signaling, the study aims to uncover the underlying mechanisms that contribute to these conditions. The approach includes examining the effects of serotonin on gut function and mood, which could lead to new treatment strategies for patients who currently have limited options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with functional gastrointestinal disorders who also experience mood disorders such as anxiety or depression.
Not a fit: Patients with gastrointestinal disorders that are not functional in nature, or those without any mood disorders, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from both gastrointestinal and mood disorders.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between serotonin and both gastrointestinal and mood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Margolis, Kara Gross — New York University
- Study coordinator: Margolis, Kara Gross
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.