Understanding the role of RELMβ in food allergies
Official title: Function of RELMβ in oral tolerance breakdown in food allergy
Funded at Boston Children's Hospital · NIH-11093958 · Data updated 2026-11-12
This study is looking at how a substance called RELMβ might affect food allergies in kids, with the hope of finding new ways to predict and manage these allergies better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 9, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,940 |
| NIH project number | 5K23AI155940-05 |
| Project ID | NIH-11093958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with food allergies.
✕Less likely to help
Patients who do not have food allergies or are older than 11 years may not benefit from this research.
What this research studies
This research investigates how RELMβ, a potential biomarker, influences food allergies in children. By studying both animal models and children with food allergies, the project aims to uncover new mechanisms behind allergic responses. The goal is to identify reliable biomarkers that can predict the severity and onset of food allergies, which could lead to better management and treatment options for affected individuals. The research will span five years and will provide training for Dr. Crestani to become an expert in this field.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for children with food allergies.
How similar studies have gone: Other research has shown promise in identifying biomarkers for food allergies, but this specific approach focusing on RELMβ is relatively novel.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Crestani, Elena — Boston Children's Hospital
- Study coordinator: Crestani, Elena
Related research
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New Horizons in Food Allergy Prevention and Treatment
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Food allergy outcomes by race/ethnicity from infancy through adolescence
This study follows children with food allergies over time to understand how race and ethnicity relate to allergy management, outcomes, and quality of life.
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Gut-brain links in food allergy responses
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Targeting gut microbes to restore food-tolerance in adults
Aims to understand how gut bacteria and the lining of the gut interact to keep people with food allergies tolerant to what they eat.
-
Environment and early-life exposures shaping food allergy in children
This grant looks at how a child’s first year and their home environment may influence whether they develop food allergies, focusing on indoor exposures and microbes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.