Understanding the role of protein barriers in blood vessel function
Novel regulators, components and function of endothelial diaphragms
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-10806940
This study is looking at tiny structures in blood vessels that help keep them healthy and working properly, especially in relation to diseases like heart attacks and cancer, and it focuses on a specific protein that plays a key role in their function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10806940 on ClinicalTrials.gov |
What this research studies
This research investigates endothelial diaphragms, which are protein structures in blood vessels that help regulate permeability and immune responses. By studying these diaphragms and their components, the research aims to uncover how they contribute to maintaining healthy blood vessel function and respond to various diseases. The approach includes examining the role of a specific protein, Plasmalemma Vesicle Associated Protein (PV1), which is crucial for the formation of these diaphragms. Insights gained from this research could lead to new therapeutic strategies for conditions like heart attacks and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with conditions affecting blood vessel function or those at risk for vascular diseases.
Not a fit: Patients with non-vascular related conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vascular-related diseases and enhance our understanding of immune responses.
How similar studies have performed: Other research has shown promising results in understanding vascular permeability and immune responses, indicating that this approach has potential for success.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STAN, RADU VIRGIL — DARTMOUTH COLLEGE
- Study coordinator: STAN, RADU VIRGIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.