Understanding the role of Paneth cells in Crohn's disease and inflammation
Paneth cell heterogeneity in infection and inflammation
This study is looking at how special cells in the gut, called Paneth cells, work in people with Crohn's disease to find out why they might not be functioning properly and to explore new treatment options for those who aren't getting better with usual therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11092768 on NIH RePORTER |
What this research studies
This research investigates how Paneth cells, which are important for gut health, behave in patients with Crohn's disease. By using advanced techniques like single-cell transcriptomics, the study aims to identify different types of Paneth cells and how they respond to infections and inflammation. The researchers are particularly focused on understanding the defects in these cells that may lead to the onset of Crohn's disease and exploring new therapeutic options for patients who do not respond to standard treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease, especially those who have not responded to existing therapies.
Not a fit: Patients with other forms of inflammatory bowel disease or those without Crohn's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Crohn's disease, improving outcomes for patients who currently have limited options.
How similar studies have performed: Previous research has shown promise in understanding the role of immune cells in inflammatory bowel diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Gao, Nan — Rutgers Biomedical and Health Sciences
- Study coordinator: Gao, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.