Understanding the role of microglia in Alzheimer's disease
Dissecting the origin, regulation and function of microglial subsets in Alzheimer's disease
This study is looking at how certain immune cells in the brain, called microglia, play a role in Alzheimer's disease, and it aims to find new ways to help treat the condition, especially for older adults, by involving patients in providing samples or sharing their experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11056156 on NIH RePORTER |
What this research studies
This research investigates how specific types of immune cells in the brain, known as microglia, contribute to the development and progression of Alzheimer's disease. By examining genetic factors and using advanced techniques like single-cell RNA sequencing, the study aims to uncover the origins and functions of a unique subset of microglia associated with disease. This could lead to new therapeutic targets for treating Alzheimer's disease, particularly in older adults. Patients may be involved in providing biological samples or participating in observational assessments to help advance this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults aged 65 and above, particularly those with or at risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target the underlying causes of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding microglial functions in Alzheimer's, indicating that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Li, Qingyun — Washington University
- Study coordinator: Li, Qingyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.