Understanding the role of microglia in Alzheimer's disease
Official title: Dissecting the origin, regulation and function of microglial subsets in Alzheimer's disease
Funded at Washington University · NIH-11056156 · Data updated 2026-11-12
This study is looking at how certain immune cells in the brain, called microglia, play a role in Alzheimer's disease, and it aims to find new ways to help treat the condition, especially for older adults, by involving patients in providing samples or sharing their experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $542,151 |
| NIH project number | 5R01AG078512-03 |
| Project ID | NIH-11056156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults aged 65 and above, particularly those with or at risk for Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without any risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how specific types of immune cells in the brain, known as microglia, contribute to the development and progression of Alzheimer's disease. By examining genetic factors and using advanced techniques like single-cell RNA sequencing, the study aims to uncover the origins and functions of a unique subset of microglia associated with disease. This could lead to new therapeutic targets for treating Alzheimer's disease, particularly in older adults. Patients may be involved in providing biological samples or participating in observational assessments to help advance this understanding.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target the underlying causes of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding microglial functions in Alzheimer's, indicating that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Li, Qingyun — Washington University
- Study coordinator: Li, Qingyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.