Understanding the role of long non-coding RNAs in breast cancer
Official title: Mechanistic Interrogation of Long Non-coding RNAs using Photocatalytic Proximity Labeling and CRISPR Phenotypic Profiling
Funded at Princeton University · NIH-11076701 · Data updated 2026-11-12
This study is looking at special RNA molecules that help control how genes work in breast cancer, and it's trying to find new ways to see how these molecules interact with proteins and other RNAs in cells to better understand how they might affect cancer growth and spread.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM154140-02 |
| Project ID | NIH-11076701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with advanced or metastatic disease.
✕Less likely to help
Patients with non-cancerous conditions or those not diagnosed with breast cancer may not receive any benefit from this research.
What this research studies
This research investigates the function of long non-coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in regulating gene expression and cellular processes. The study aims to develop innovative techniques to map how these lncRNAs interact with proteins and other RNA molecules within cells, particularly in the context of breast cancer. By using advanced methods like CRISPR-based profiling and photocatalytic labeling, the research seeks to uncover the mechanisms by which lncRNAs influence cancer progression and metastasis.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting lncRNAs, potentially improving treatment outcomes for breast cancer patients.
How similar studies have gone: While the exploration of lncRNAs is a growing field, this specific approach using CRISPR and photocatalytic techniques is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Knutson, Steven Douglas — Princeton University
- Study coordinator: Knutson, Steven Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.