Understanding the role of Leiomodin1 in blood vessel health
Official title: Function and Transcriptional Regulation of Leiomodin1
Funded at Augusta University · NIH-11048889 · Data updated 2026-11-12
This study is looking at a protein called LMOD1 to see how it affects blood vessel health and its role in heart disease, especially when people eat high-fat diets, so we can better understand how to keep blood vessels working well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $768,198 |
| NIH project number | 1R01HL173111-01A1 |
| Project ID | NIH-11048889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for coronary artery disease, particularly those with a family history or genetic predispositions.
✕Less likely to help
Patients with established coronary artery disease who are not genetically predisposed to changes in LMOD1 may not benefit from this research.
What this research studies
This research investigates how Leiomodin1 (LMOD1), a protein linked to vascular smooth muscle cells, affects the health of blood vessels and contributes to coronary artery disease. By using advanced techniques like lineage tracing and single-cell analysis, the study aims to uncover the function and regulation of LMOD1 in living organisms. Researchers will explore how changes in LMOD1 impact vascular smooth muscle cells and their role in maintaining normal blood vessel function, particularly under stress conditions such as high-fat diets.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for preventing or treating coronary artery disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of vascular smooth muscle cells in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Miano, Joseph M — Augusta University
- Study coordinator: Miano, Joseph M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.