Understanding the role of Junctophilin-1 in heart function
Official title: Junctophilin-1 in the heart
Funded at University of Iowa · NIH-11027595 · Data updated 2026-11-12
This study is looking at a protein called Junctophilin-1 to see how it helps the heart work properly, especially in people with heart failure, by understanding how it affects heart contractions and signals that keep the heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | March 10, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $684,937 |
| NIH project number | 1R01HL176940-01 |
| Project ID | NIH-11027595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing heart failure or related cardiac conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how Junctophilin-1, a protein involved in heart muscle function, affects the heart's ability to contract and respond to signals. The study focuses on understanding the mechanisms of heart failure, particularly how disruptions in calcium signaling and cellular structures contribute to heart disease. By examining genetically modified heart cells, the research aims to uncover the role of Junctophilin-1 in maintaining healthy heart function and preventing arrhythmias.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure and related arrhythmias, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding cardiac proteins and their roles in heart function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Song, Long-Sheng — University of Iowa
- Study coordinator: Song, Long-Sheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.