Understanding the role of immune cells in Alzheimer's disease
Probing Heterogeneity of Alzheimer's Disease Using iPSCs
This study is looking at how brain immune cells called microglia might influence the progression of late-onset Alzheimer's disease, using special lab techniques to better understand their role and find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11083586 on NIH RePORTER |
What this research studies
This research investigates how microglial cells, which are immune cells in the brain, contribute to the progression of late-onset Alzheimer's disease. By using advanced techniques like CRISPR-Cas9 and pharmacological manipulation, the study aims to explore how changes in microglial function affect the accumulation of amyloid beta and the overall neuroinflammatory response in Alzheimer's. The research utilizes human induced pluripotent stem cells (iPSCs) to create microglia that can be studied in the lab, providing insights into the disease mechanisms and potential therapeutic targets. Patients may benefit from a deeper understanding of how their immune system interacts with Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk for or diagnosed with late-onset Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's disease or other forms of dementia unrelated to amyloid beta accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting immune responses in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Young-Pearse, Tracy L — Brigham and Women's Hospital
- Study coordinator: Young-Pearse, Tracy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.