Understanding the role of IgE antibodies in health and disease
Official title: Role of IgE in Homeostasis and Disease
Funded at Yale University · NIH-11032861 · Data updated 2026-11-12
This study is looking at how a type of antibody called IgE works in the body, not just in allergies, and it aims to find out what it interacts with during infections and normal health, so if you're interested in how IgE affects your health, you might be able to participate!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 12, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $786,582 |
| NIH project number | 5R01AI182061-02 |
| Project ID | NIH-11032861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals with known allergic conditions, particularly those related to food allergies.
✕Less likely to help
Patients without any history of allergic diseases or those who do not produce IgE antibodies may not benefit from this research.
What this research studies
This research investigates how Immunoglobulin E (IgE), a specific type of antibody, functions in the body beyond its known role in allergic diseases. By developing a genetic tool to enhance the stability and purification of IgE, the researchers aim to identify the specific antigens that IgE interacts with during both normal conditions and in response to infections. This approach will help clarify the protective roles of IgE and its potential contributions to maintaining health. Patients may be involved in studies that explore these interactions and their implications for allergic conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how IgE can be harnessed for better management of allergic diseases and potentially improve overall immune health.
How similar studies have gone: While the role of IgE in allergic diseases is well-documented, this research approach is novel as it seeks to explore IgE's functions in homeostasis and disease protection, which has not been extensively studied.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Medzhitov, Ruslan — Yale University
- Study coordinator: Medzhitov, Ruslan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.