Understanding the role of genetic factors in centromere function
Genetic and Epigenetic Determinants of Centromere Identity
This study looks at how certain genes and DNA features help keep chromosomes organized during cell division, which is important for preventing problems like infertility and developmental issues, and it uses fruit flies to learn more about these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11011889 on NIH RePORTER |
What this research studies
This research investigates how specific genetic and epigenetic factors determine the identity of centromeres, which are crucial for proper chromosome segregation during cell division. By using Drosophila as a model organism, the study aims to uncover the mechanisms that ensure each chromosome has a single centromere, preventing conditions like aneuploidy and infertility. The research focuses on the role of unique chromatin structures and repetitive DNA in maintaining centromere integrity and function. Patients may benefit from insights gained into the genetic causes of infertility and developmental abnormalities linked to chromosomal issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or developmental issues potentially linked to chromosomal abnormalities.
Not a fit: Patients with chromosomal conditions not related to centromere function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and developmental disorders caused by chromosomal abnormalities.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding chromosomal behavior and its implications for health.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Mellone, Barbara — University of Connecticut Storrs
- Study coordinator: Mellone, Barbara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.