Understanding the role of gamma secretase in a skin condition called hidradenitis suppurativa.
Dysregulation of Gamma Secretase in Common Acquired Hidradenitis Suppurativa
This study is looking into hidradenitis suppurativa, a painful skin condition, to understand how a protein called gamma secretase might be affecting it, especially in people who don't have known genetic issues, with the hope of finding better treatments for those who struggle with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11161854 on NIH RePORTER |
What this research studies
This research investigates hidradenitis suppurativa (HS), a chronic skin condition that causes painful lesions and scarring. The study focuses on the role of gamma secretase, a protein complex that may be dysregulated in patients with HS, particularly those without identifiable genetic mutations. By examining the immune signaling in skin cells and the factors leading to the loss of a specific protein called nicastrin, the research aims to uncover the underlying mechanisms of HS. This could lead to better understanding and potential new treatments for patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hidradenitis suppurativa, particularly those who do not have a known genetic mutation.
Not a fit: Patients with hidradenitis suppurativa who have a clear genetic mutation causing their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with hidradenitis suppurativa.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown promise in understanding similar inflammatory skin conditions through the investigation of immune signaling pathways.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Minsky, Hana Bleicher — Johns Hopkins University
- Study coordinator: Minsky, Hana Bleicher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.