Understanding the role of EWSR1 protein in cellular functions and diseases
An Integrated Biochemical and Structural Approach to Delineating the Biology of EWSR1
This study is looking at a protein called EWSR1 to understand how it works in our cells and how problems with it might lead to neurodegenerative diseases and childhood cancers, with the hope that this knowledge could help develop new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10884402 on NIH RePORTER |
What this research studies
This research investigates the EWSR1 protein, which plays a crucial role in cellular processes like RNA processing and DNA repair. It focuses on how low-complexity amino acid sequences in EWSR1 contribute to both normal cellular functions and the development of neurodegenerative diseases and pediatric cancers. By using advanced biochemical and structural techniques, the study aims to uncover the mechanisms behind EWSR1's function and its pathological assemblies. Patients may benefit from insights gained about EWSR1's role in diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases or pediatric cancers related to EWSR1 dysfunction.
Not a fit: Patients with conditions unrelated to EWSR1 or those not affected by neurodegenerative diseases or pediatric cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases and pediatric cancers by targeting the mechanisms involving EWSR1.
How similar studies have performed: Other research has shown promising results in understanding RNA-binding proteins and their roles in diseases, indicating that this approach has potential for success.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Libich, David Steven — University of Texas Hlth Science Center
- Study coordinator: Libich, David Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.