Understanding the role of epigenetics in colorectal cancer without APC mutations
Epigenetic dysregulation in APC-negative colorectal cancer
This study is looking at colorectal cancer in younger African Americans, especially those whose cancer doesn't have certain gene mutations, to understand how changes in DNA might be causing this type of cancer, with the goal of finding better ways to prevent and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10830970 on NIH RePORTER |
What this research studies
This research investigates the unique characteristics of colorectal cancer (CRC) that occurs in younger African Americans, particularly focusing on cases that do not have mutations in the APC gene. The study aims to explore how epigenetic changes, specifically DNA methylation patterns, contribute to the development and progression of these cancers. By analyzing tumor samples and their genetic profiles, researchers hope to uncover the underlying mechanisms that lead to this aggressive form of CRC. The findings could provide insights into targeted prevention and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are younger African American individuals diagnosed with colorectal cancer, especially those without APC mutations.
Not a fit: Patients with colorectal cancer who are older or have APC mutations may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for colorectal cancer, particularly in younger African American patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in cancer, but this specific focus on APC mutation-negative CRC is relatively novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Ellis, Nathan a. — University of Arizona
- Study coordinator: Ellis, Nathan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.