Understanding the role of epigenetic changes in colorectal cancer
A Molecular Case Series: Deep Cellular and Spatial Epigenetic Characterization of Human Colorectal Cancer
This study is looking at how changes in our DNA might play a role in the development of colorectal cancer, by checking tissue samples to see when and where these changes happen, which could help us understand the early signs of cancer and find ways to intervene.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10677611 on NIH RePORTER |
What this research studies
This research investigates how epigenetic changes, specifically DNA methylation, contribute to the development and progression of colorectal cancer. By analyzing tissue samples, the study aims to identify when and where these changes occur, particularly in genes that are crucial for cell development and differentiation. The approach includes examining both cancerous and histologically normal colorectal tissues to understand the accumulation of epigenetic marks over time. This could provide insights into the early stages of cancer development and potential intervention points.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal cancer or those at high risk for developing the disease.
Not a fit: Patients with advanced colorectal cancer who are already undergoing treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and treatment of colorectal cancer.
How similar studies have performed: Previous research has shown that understanding epigenetic changes can lead to significant advancements in cancer treatment, suggesting this approach has potential for success.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Spix, Nathan J. — Van Andel Research Institute
- Study coordinator: Spix, Nathan J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.