Understanding the role of eIF2A in protein synthesis regulation
Official title: eIF2A in translational control
Funded at Cleveland State University · NIH-10539309 · Data updated 2026-11-12
This study is looking at a protein called eIF2A to understand how it helps start the process of making proteins in our cells, especially when other methods are blocked, and it hopes to find out how this knowledge could help people with diseases like cancer and metabolic disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 15, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $292,046 |
| NIH project number | 5R01GM128981-04 |
| Project ID | NIH-10539309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancers or metabolic disorders such as diabetes and fatty liver disease.
✕Less likely to help
Patients with conditions unrelated to protein synthesis regulation or those not affected by the diseases being studied may not receive benefit from this research.
What this research studies
This research investigates the function of eIF2A, a protein involved in the initiation of protein synthesis in eukaryotic cells. It aims to clarify how eIF2A interacts with other initiation factors and its role in promoting the binding of essential molecules to ribosomes, especially under conditions where other pathways are inhibited. By studying the mechanisms of eIF2A, the research seeks to uncover its potential implications in various diseases, including cancers and metabolic disorders. Patients may benefit from insights gained about how protein synthesis is regulated in their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers and metabolic disorders by targeting the mechanisms of protein synthesis.
How similar studies have gone: While the specific role of eIF2A is still being explored, previous research has shown success in understanding other initiation factors in protein synthesis, indicating potential for breakthroughs in this area.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Komar, Anton a. — Cleveland State University
- Study coordinator: Komar, Anton a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.