Understanding the role of diverse oligodendrocytes in Alzheimer's disease
Oligodendrocyte heterogeneity in Alzheimer' s disease
This study is looking at how certain brain cells called oligodendrocytes might play a role in Alzheimer's disease, using advanced techniques to understand their genetics and functions better, so we can learn more about the disease and potentially find new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11056766 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms of Alzheimer's disease (AD) by focusing on oligodendrocytes, which are crucial cells in the brain that support neurons. The study employs advanced techniques to analyze genetic and regulatory networks in these cells, using data from both human samples and mouse models. By mapping these networks at a single-cell level, the research aims to uncover new insights into how oligodendrocytes contribute to AD pathology. Additionally, it explores the role of specific proteins involved in lipid metabolism that may influence the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients under the age of 65 or those without any signs of Alzheimer's disease are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for Alzheimer's disease, potentially improving treatment options for patients.
How similar studies have performed: Previous research has shown promise in understanding the role of oligodendrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Swarup, Vivek — University of California-Irvine
- Study coordinator: Swarup, Vivek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.