Understanding the role of different cells in normal and Trisomy 21-affected placentas
Trophoblast progenitor heterogeneity and function in normal and Trisomy 21-affected placentae
This study is looking at special cells in the placenta that help babies grow during early pregnancy, especially in cases like Down syndrome, to learn more about how these cells work and what might go wrong, which could help improve pregnancy health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10931726 on NIH RePORTER |
What this research studies
This research investigates the cellular diversity and functions of trophoblasts, which are crucial for fetal development, particularly during early pregnancy. By utilizing advanced techniques like single-cell analysis and stem cell modeling, the study aims to explore how these cells differentiate and function in both normal placentas and those affected by Trisomy 21. The research will involve deriving trophoblast stem cells from human placentas to better understand their roles and potential abnormalities in conditions like Down syndrome. This could lead to insights into placental health and fetal growth.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals, particularly those carrying fetuses diagnosed with Trisomy 21 or other genetic conditions.
Not a fit: Patients who are not pregnant or those with pregnancies that are not affected by genetic abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve our understanding of placental function and its impact on fetal development, potentially leading to better outcomes for pregnancies affected by genetic conditions.
How similar studies have performed: Other research has shown promise in understanding trophoblast biology and its implications for pregnancy outcomes, indicating that this approach is building on established findings.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Parast, Mana M — University of California, San Diego
- Study coordinator: Parast, Mana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.