Understanding the role of DDX41 in blood disorders

Who could benefit from this research

What this research studies

This research investigates how mutations in the DDX41 gene contribute to myelodysplastic syndromes (MDS), which can lead to acute myeloid leukemia (AML). The study aims to uncover the molecular and cellular mechanisms by which DDX41 mutations cause blood cell abnormalities and apoptosis. By using models such as zebrafish and mice, researchers will explore the effects of DDX41 loss on hematopoietic cells and identify which blood cell lineages are most affected. The ultimate goal is to develop targeted therapies for patients with DDX41-related MDS.

Why it matters

Where this research is happening

• Northwestern University at Chicago
  Chicago, United States Active

Researchers

• Principal investigator: Bi, Honghao — Northwestern University at Chicago
• Study coordinator: Bi, Honghao

Related research

Other NIH-funded projects on the same topics.

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• Whole-genome sequencing to refine risk in myelodysplastic syndromes (MDS) for older adults

  This project uses clinical whole-genome sequencing to improve genetic profiling and better predict how MDS will progress in older patients.

  NIH research Washington University · Saint Louis, United States · NIH-11415218

• Targeting gasdermin D to treat myelodysplastic syndromes in people with bone marrow inflammation

  A research project aims to find new ways to treat myelodysplastic syndromes by blocking a protein (gasdermin D) involved in harmful bone marrow inflammation.

  NIH research Northwestern University · Chicago, United States · NIH-11371104

• Understanding why some MDS patients relapse after a stem cell transplant

  A study of patients with myelodysplastic syndromes after stem cell transplant to learn the cellular changes and gene activity that lead to relapse, with the goal of guiding future treatments.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11350441

• Risk factors and inflammation biomarkers for cardiovascular disease in older adults with myelodysplastic syndromes

  A study focuses on older adults with myelodysplastic syndromes to understand why they have higher cardiovascular risk and how inflammatory proteins in the blood might help predict it.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11335686

• Therapeutic targeting of transcription-epigenetic defects in SF3B1-mutant MDS

  A training-focused grant to help a clinician-scientist develop therapies for adults with a common bone marrow failure condition called SF3B1-mutant myelodysplastic syndrome (MDS).

  NIH research Yale University · New Haven, United States · NIH-11332844

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.