Understanding the role of Cytochrome P450 2E1 in liver health and disease
Official title: Regulation and Consequences of Cytochrome P450 2E1
Funded at Medical University of South Carolina · NIH-10884292 · Data updated 2026-11-12
This study is looking at how a liver enzyme called CYP2E1 works and how it can be controlled, especially in people dealing with liver issues from alcohol or obesity, to find new ways to help improve liver health and treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $368,932 |
| NIH project number | 5R35GM150843-02 |
| Project ID | NIH-10884292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with liver conditions, particularly those affected by alcohol-related liver damage or metabolic disorders.
✕Less likely to help
Patients with non-liver related health issues or those who do not have any metabolic or liver conditions may not benefit from this research.
What this research studies
This research investigates the function and regulation of Cytochrome P450 2E1 (CYP2E1), a critical enzyme involved in liver metabolism. The study aims to uncover how CYP2E1 is regulated and its effects on liver health, particularly in conditions like alcoholic liver damage and obesity. Using advanced laboratory techniques and animal models, the research will explore the potential therapeutic implications of targeting CYP2E1 for improving liver function and treatment outcomes. Patients may benefit from insights gained about liver health and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for liver diseases and improve treatment strategies for conditions like alcoholic liver damage.
How similar studies have gone: Previous research has shown promising results in understanding the role of CYP2E1 in liver health, indicating that this area of study has potential for significant advancements.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Hartman, Jessica Helene — Medical University of South Carolina
- Study coordinator: Hartman, Jessica Helene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.