Understanding the role of circular DNA in cancer development
Software and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNA
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10903740
This study is looking at a special type of DNA found in some cancers that can make tumors grow faster, and it's creating a helpful tool for researchers to better understand this DNA and find new ways to treat cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10903740 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of extrachromosomal DNA (ecDNA) in cancer, particularly how it contributes to the amplification of oncogenes that drive tumor growth. The project aims to develop user-friendly software and algorithms that help researchers analyze the structure and function of ecDNA, which is found in about 25% of cancers. By creating a tool called CAPER, the research will allow for easier access to complex data analysis, facilitating better understanding of cancer mechanisms and potential vulnerabilities for treatment. The project also emphasizes collaboration and education to promote the use of this software in the scientific community.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit extrachromosomal DNA characteristics.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve ecDNA amplification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for various cancers.
How similar studies have performed: Other research has shown promising results in understanding the role of ecDNA in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAFNA, VINEET — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BAFNA, VINEET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Genes, Cancer-Promoting Gene, Cancers