Understanding the role of centrioles and cilia in various diseases
Genetic analysis of centrioles and cilia
This study is looking at how problems with tiny structures in our cells called centrioles and cilia can cause health issues like some cancers and other diseases, and it aims to find out how these problems affect things like fertility and breathing, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11088460 on NIH RePORTER |
What this research studies
This research investigates how defects in centrioles and cilia, which are essential structures in our cells, can lead to various health issues, including certain cancers and ciliopathies. By using advanced techniques like cryo-electron microscopy, the team aims to uncover the mechanisms behind these defects and their impact on bodily functions such as fertility and respiratory health. The study will involve genetic and biochemical analyses to explore the roles of specific proteins that are crucial for the structure and function of cilia. Patients may benefit from insights gained about these conditions and potential new treatment avenues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with ciliopathies, congenital brain anomalies, or related health issues.
Not a fit: Patients without any genetic or structural issues related to cilia or centrioles may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with ciliopathies and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of cilia in various diseases, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Dutcher, Susan K — Washington University
- Study coordinator: Dutcher, Susan K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.