Understanding the role of CD8 T cells in skin infections caused by leishmania parasites
Distinct functions for CD8 T cells in cutaneous leishmaniasis
This study is looking at how a type of immune cell called CD8 T cells works in cutaneous leishmaniasis, a skin disease caused by parasites, to see if they help fight the infection or cause more skin damage, which could lead to better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11011265 on NIH RePORTER |
What this research studies
This research investigates how CD8 T cells function in cutaneous leishmaniasis, a disease caused by leishmania parasites that can lead to various skin lesions. The study aims to understand the dual role of these immune cells, which can either protect against the infection or contribute to tissue damage. By examining the tissue microenvironment, the researchers will explore how factors like hypoxia and specific interleukins influence the behavior of CD8 T cells. This could provide insights into why current treatments are often ineffective and help identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cutaneous leishmaniasis, particularly those experiencing chronic or severe symptoms.
Not a fit: Patients with other types of leishmaniasis or those who do not have a confirmed diagnosis of cutaneous leishmaniasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cutaneous leishmaniasis, potentially reducing the severity of the disease and enhancing patient outcomes.
How similar studies have performed: Previous research has shown that understanding immune responses in infectious diseases can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Novais, Fernanda — Ohio State University
- Study coordinator: Novais, Fernanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.