Understanding the role of breast tissue in breast cancer risk
Stromal contributions to breast carcinogenesis
This research looks at how the supportive tissue in the breast, called stroma, might influence a woman's risk of developing breast cancer, especially in its early stages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11129912 on NIH RePORTER |
What this research studies
Our breasts contain special supportive tissue called stroma, which helps keep them healthy and functioning normally. This tissue also plays a role in preventing abnormal cell growth. This project explores how changes in this stromal tissue might contribute to the very first steps of breast cancer development. We are focusing on women who have benign breast disease or high mammographic breast density, as these are known to increase breast cancer risk. By studying existing data and biopsy samples from large groups of women, we hope to uncover the molecular changes happening early on.
Who could benefit from this research
Good fit: This research is relevant to women with benign breast disease or high mammographic breast density, as these conditions are central to the study's focus.
Not a fit: Patients without a history of benign breast disease or high mammographic density may not directly benefit from the specific findings of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify women at higher risk for breast cancer earlier and potentially develop new strategies for prevention or early intervention.
How similar studies have performed: While the role of stroma in advanced cancer is known, this investigation is conceptually and methodologically novel in its focus on the very early stages of breast carcinogenesis.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Yaghjyan, Lusine — University of Florida
- Study coordinator: Yaghjyan, Lusine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.