Understanding the role of blood clotting in acute pancreatitis
Deciphering Pancreatitis Microenvironment through Intravital Imaging
This study is looking at how a blood clotting protein called thrombin might play a role in causing acute pancreatitis, a painful stomach condition, and aims to find new ways to treat it better for people who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11061833 on NIH RePORTER |
What this research studies
This research investigates how blood clotting factors, particularly thrombin, contribute to the development of acute pancreatitis, a serious gastrointestinal condition. Using advanced imaging techniques and genetically modified mouse models, the study aims to explore the interactions between trypsin and coagulation processes in the pancreas. By examining these mechanisms, researchers hope to identify new therapeutic targets and improve drug delivery to the inflamed pancreas, potentially leading to better treatment options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute pancreatitis or those at high risk for developing the condition.
Not a fit: Patients with chronic pancreatitis or those who do not have any pancreatic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for acute pancreatitis, reducing hospitalizations and healthcare costs.
How similar studies have performed: Previous research has shown promising results in understanding the role of thrombin in pancreatitis, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Bi, Yan — Mayo Clinic Jacksonville
- Study coordinator: Bi, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.