Understanding the role of blood clotting in acute pancreatitis
Official title: Deciphering Pancreatitis Microenvironment through Intravital Imaging
Funded at Mayo Clinic Jacksonville · NIH-11061833 · Data updated 2026-11-12
This study is looking at how a blood clotting protein called thrombin might play a role in causing acute pancreatitis, a painful stomach condition, and aims to find new ways to treat it better for people who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $578,659 |
| NIH project number | 5R01DK139207-02 |
| Project ID | NIH-11061833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute pancreatitis or those at high risk for developing the condition.
✕Less likely to help
Patients with chronic pancreatitis or those who do not have any pancreatic disorders may not benefit from this research.
What this research studies
This research investigates how blood clotting factors, particularly thrombin, contribute to the development of acute pancreatitis, a serious gastrointestinal condition. Using advanced imaging techniques and genetically modified mouse models, the study aims to explore the interactions between trypsin and coagulation processes in the pancreas. By examining these mechanisms, researchers hope to identify new therapeutic targets and improve drug delivery to the inflamed pancreas, potentially leading to better treatment options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for acute pancreatitis, reducing hospitalizations and healthcare costs.
How similar studies have gone: Previous research has shown promising results in understanding the role of thrombin in pancreatitis, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Bi, Yan — Mayo Clinic Jacksonville
- Study coordinator: Bi, Yan
Related research
Other NIH-funded projects on the same topics.
-
Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.
-
Lymphatic roles in pancreatitis and recovery
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.