Understanding the role of ATG3 in diseases like cancer and neurodegeneration
Disease consequences and regulation of autophagy-independent ATG3 activity
This study is looking at a gene called ATG3 that helps our cells deal with stress, especially in a patient with a change in this gene who has a serious brain development issue, to see how it affects cell health and could relate to other diseases like cancer and neurodegeneration.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11015778 on NIH RePORTER |
What this research studies
This research investigates the ATG3 gene, which is crucial for a cellular process called autophagy that helps cells manage stress. The study focuses on a patient with a mutation in the ATG3 gene who has a severe neurodevelopmental disease, exploring how this mutation affects not only autophagy but also other important cellular functions. By developing new tools to study these effects, the research aims to uncover the broader implications of ATG3's role in various diseases, including cancer and neurodegeneration. This work will contribute to a deeper understanding of how cellular processes can impact health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodevelopmental disorders or those affected by diseases related to autophagy dysfunction.
Not a fit: Patients with conditions unrelated to autophagy or the specific functions of the ATG3 gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases associated with autophagy dysregulation, potentially improving outcomes for patients with cancer and neurodegenerative conditions.
How similar studies have performed: While the specific focus on ATG3's non-canonical activities is novel, research on autophagy and its implications in various diseases has shown promising results in the past.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Guinn, Emily Delgado — Yale University
- Study coordinator: Guinn, Emily Delgado
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.