Understanding the role of ASH1L in blood cell development and leukemia
Molecular analysis of ASH1L
This study is looking at a protein called ASH1L that helps blood stem cells grow and survive, especially in leukemia, to find out how it works with other proteins to control important genes, which could lead to new treatments for blood cancers that might help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10640283 on NIH RePORTER |
What this research studies
This research investigates the ASH1L protein, which plays a crucial role in the growth and survival of blood stem cells and is often found at elevated levels in certain types of leukemia. The project aims to explore how ASH1L interacts with various histone proteins to regulate gene expression, particularly focusing on genes that are important for blood cell development. By analyzing the molecular mechanisms of ASH1L, the research seeks to uncover potential therapeutic targets for treating blood cancers. Patients may benefit from insights gained about ASH1L's role in leukemia progression and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with leukemia, particularly those with mixed lineage leukemia or acute lymphoblastic leukemia.
Not a fit: Patients with solid tumors or non-cancerous conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with leukemia by targeting the mechanisms involving ASH1L.
How similar studies have performed: Previous research has shown promising results in targeting epigenetic regulators like ASH1L in cancer treatment, indicating a potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kutateladze, Tatiana G — University of Colorado Denver
- Study coordinator: Kutateladze, Tatiana G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.