Understanding the role of ApoE in Alzheimer's disease using new rat models
Official title: Impact of ApoE in Novel Rat Models of Late-Onset AD
Funded at University of Rhode Island · NIH-11030756 · Data updated 2026-11-12
This study is looking at how a specific gene called ApoE4 influences the development of late-onset Alzheimer's disease using rat models, which might help us find better treatments for people living with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project start | February 15, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $236,250 |
| NIH project number | 5R21AG085087-02 |
| Project ID | NIH-11030756 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for late-onset Alzheimer's disease, particularly those with the ApoE4 genotype.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those without the ApoE4 genotype may not benefit from this research.
What this research studies
This research investigates how the ApoE4 gene affects the development and progression of late-onset Alzheimer's disease (LOAD) using novel rat models. Unlike traditional studies that rely on transgenic mice, this approach aims to create more accurate representations of human disease by utilizing rat models that better mimic the complexities of Alzheimer's pathology. The study will explore the interactions of various cell types involved in Alzheimer's, including neurons, astrocytes, and vascular cells, to provide insights into potential therapeutic interventions. By understanding these mechanisms, the research aims to pave the way for more effective treatments for patients with LOAD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from late-onset Alzheimer's disease.
How similar studies have gone: While traditional studies have focused on transgenic mice, this novel approach using rat models has not been extensively tested, making it a potentially groundbreaking method.
Where this research is happening
-
University of Rhode Island
Kingston, United States Active
Researchers
- Principal investigator: Van Nostrand, William E. — University of Rhode Island
- Study coordinator: Van Nostrand, William E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.