Understanding the role of antinuclear antibodies in autoimmune disease risk
Genome and Phenome to Define Disease Risk with Antinuclear Antibodies
This study is looking at how antinuclear antibodies (ANA) can help doctors diagnose lupus and understand what a positive ANA test means for people who don’t have autoimmune diseases, especially focusing on patients with joint or muscle pain to make sure they get the right diagnosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10827936 on NIH RePORTER |
What this research studies
This research investigates the significance of antinuclear antibodies (ANA) in diagnosing systemic lupus erythematosus (SLE) and understanding their implications in individuals without autoimmune diseases. By analyzing clinical and genetic data, the study aims to clarify the consequences of a positive ANA test and improve predictions for those at risk of developing SLE. Patients with joint or muscle pain who test positive for ANA will be a focus, as the research seeks to prevent misdiagnosis and enhance diagnostic accuracy.
Who could benefit from this research
Good fit: Ideal candidates include individuals who test positive for antinuclear antibodies and may or may not have symptoms of autoimmune diseases.
Not a fit: Patients who do not have antinuclear antibodies or those with established autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better risk assessment for patients with antinuclear antibodies.
How similar studies have performed: Previous research has shown promise in using genetic and clinical data to improve disease risk prediction, making this approach both relevant and potentially impactful.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Kawai, Vivian K — Vanderbilt University Medical Center
- Study coordinator: Kawai, Vivian K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.