Understanding the role of antibodies in long-term effects after Ebola infection
Official title: Defining the protective or pathologic role of antibodies in Post-Ebola Syndrome
Funded at Washington State University · NIH-10897769 · Data updated 2026-11-12
This study is looking at the long-term health problems that people who survived Ebola face, especially how certain antibodies might be linked to their ongoing symptoms like joint and muscle pain, and it’s for those who have recovered from Ebola and want to understand their health better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $45,214 |
| NIH project number | 5F31AI174753-02 |
| Project ID | NIH-10897769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have survived Ebola virus disease and are experiencing symptoms of post-Ebola syndrome.
✕Less likely to help
Patients who have not been infected with the Ebola virus or do not exhibit symptoms of post-Ebola syndrome may not benefit from this research.
What this research studies
This research investigates the long-term health issues faced by survivors of Ebola virus disease, known as post-Ebola syndrome (PES). It aims to understand how antibodies, both virus-specific and autoimmune, contribute to the symptoms experienced by these survivors. By analyzing a cohort of Ebola survivors and their contacts from Sierra Leone, the study will explore the mechanisms behind PES and the potential persistence of the virus in the body. Patients will be assessed for various symptoms, including joint and muscle pain, to determine the relationship between antibody responses and these long-term effects.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of post-Ebola syndrome, improving the quality of life for survivors.
How similar studies have gone: While there has been limited research on post-Ebola syndrome, the investigation of autoimmune responses in viral infections has shown promise in other contexts, suggesting potential for success in this area.
Where this research is happening
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Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Velazquez, Jalene — Washington State University
- Study coordinator: Velazquez, Jalene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.