Understanding the role of a specific RNA in kidney disease
Deciphering the role of long noncoding RNA Pvt1 in preclinical models of ADPKD
This study is looking at a specific RNA called Pvt1 to see how it affects kidney cysts in people with autosomal dominant polycystic kidney disease (ADPKD), using special mice models to find new ways to help treat this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10997397 on NIH RePORTER |
What this research studies
This research investigates the role of a long noncoding RNA called Pvt1 in autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder affecting kidney function. The study uses preclinical models, including genetically modified mice, to explore how manipulating Pvt1 expression can influence cyst formation in the kidneys. By employing advanced techniques like adeno-associated virus delivery systems, the researchers aim to identify potential therapeutic targets that could lead to new treatment options for patients with ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease, particularly those with a genetic mutation in the PKD1 or PKD2 genes.
Not a fit: Patients with other forms of kidney disease or those without a genetic predisposition to ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or treating ADPKD, potentially improving kidney health and quality of life for affected patients.
How similar studies have performed: While the role of long noncoding RNAs in kidney disease is a relatively novel area of research, preliminary findings suggest that similar approaches have shown promise in other conditions, indicating potential for success.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Aboudehen, Karam — State University New York Stony Brook
- Study coordinator: Aboudehen, Karam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.