Understanding the role of a protein in motor circuit development and related diseases
Essential role of Stasimon in motor circuit development and disease
This study is looking at how a protein called Stasimon affects the growth of the nerve circuits that help us swallow and breathe, which could help us understand more about spinal muscular atrophy (SMA) and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10745697 on NIH RePORTER |
What this research studies
This research investigates how a specific protein, Stasimon, influences the development of motor circuits that control essential functions like swallowing and breathing. By examining the interactions between spinal motor neurons and other neural components, the study aims to uncover the mechanisms behind motor system disorders, particularly spinal muscular atrophy (SMA). The approach involves analyzing synaptic activity and its impact on motor neuron function during early development, which could lead to insights into the causes of motor neuron loss and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with spinal muscular atrophy or other motor neuron disorders.
Not a fit: Patients with motor disorders not related to synaptic dysfunction or those without a genetic component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating motor neuron diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding motor circuit development and its implications for diseases like SMA, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Pellizzoni, Livio — Columbia University Health Sciences
- Study coordinator: Pellizzoni, Livio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.