Understanding the role of a gene in brain development related to breathing in newborns
Official title: Role of Gsx2 in hindbrain neurogenesis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11159122 · Data updated 2026-11-12
This study is looking at how a gene called Gsx2 influences the development of breathing-related brain cells in newborns, especially to help understand breathing problems like sudden infant death syndrome (SIDS), with the hope of finding better treatments for babies at risk.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 19, 2025 |
| Project end | May 18, 2028 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32HD118646-01 |
| Project ID | NIH-11159122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns and infants, particularly those at risk for breathing disorders or SIDS.
✕Less likely to help
Patients who are older than two years or do not have any breathing-related conditions may not benefit from this research.
What this research studies
This research investigates how the Gsx2 gene affects the development of neurons responsible for breathing in newborns. By studying mice with mutations in this gene, researchers aim to uncover the molecular and genetic factors that contribute to breathing disorders, particularly in cases of sudden infant death syndrome (SIDS). The approach involves analyzing the impact of Gsx2 on specific brain regions and neuronal types that are crucial for regulating breathing. The ultimate goal is to develop targeted therapies that could improve outcomes for infants at risk of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent breathing failures in newborns, potentially reducing the risk of SIDS.
How similar studies have gone: Other research has shown promising results in understanding genetic factors related to neurogenesis and breathing regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Riccetti, Matthew — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Riccetti, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.