Understanding the role of a brain protein in Lewy Body Dementia and Alzheimer's disease

Who could benefit from this research

What this research studies

This research investigates the role of α-synuclein, a protein in the brain, in conditions like Lewy Body Dementia and Alzheimer's disease. It focuses on distinguishing between normal and abnormal forms of a specific phosphorylated version of this protein, which is crucial for understanding the disease processes. By examining how this protein behaves under different conditions, the research aims to uncover insights that could lead to better treatments for these dementias. Patients may benefit from improved diagnostic markers and potential therapeutic interventions based on the findings.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Ramalingam, Nagendran — Brigham and Women's Hospital
• Study coordinator: Ramalingam, Nagendran

Related research

Other NIH-funded projects on the same topics.

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• Synthetic protein mimetics to treat Lewy Body Dementia

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  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11619902

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• New biomarkers to distinguish LATE from Alzheimer’s disease in dementia

  A study to develop blood and CSF tests that can tell apart LATE from Alzheimer’s disease in people with dementia.

  NIH research North Carolina Central University · Durham, United States · NIH-11619734

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.