Understanding the risks and benefits of bisphosphonate medications for preventing fractures
Coordination of Consortium Activities for RFA-AG-22-018
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11003476
This study looks at why fewer people are using bisphosphonate medications, which help prevent fractures in those with osteoporosis, and it aims to find out more about the risks of rare thigh bone fractures from long-term use, so that patients and doctors can make better choices about osteoporosis treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11003476 on ClinicalTrials.gov |
What this research studies
This research investigates the declining use of bisphosphonate medications, which are prescribed to prevent fractures in individuals with osteoporosis. It aims to analyze existing datasets to assess the risks of atypical femur fractures associated with long-term bisphosphonate use and to explore strategies such as drug holidays. By combining data from large cohort studies, the research seeks to provide clearer evidence for patients and healthcare providers regarding the safety and efficacy of these medications. The goal is to help patients make informed decisions about their osteoporosis treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with osteoporosis who are considering or currently using bisphosphonate medications.
Not a fit: Patients who do not have osteoporosis or those who are not considering bisphosphonate treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help patients better understand the risks and benefits of bisphosphonate medications, potentially leading to improved treatment adherence and reduced fracture risk.
How similar studies have performed: Previous research has shown that analyzing large datasets can provide valuable insights into medication risks and benefits, indicating that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLACK, DENNIS M — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: BLACK, DENNIS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.