Understanding the risk of coronary artery lesions and their potential to rupture
Biomechanical Indices for Coronary Lesion Rupture Risk and Lesion Prognostication
This study is looking at how the physical characteristics of blockages in your heart's arteries can help doctors figure out which ones are more likely to cause serious heart problems, so they can better predict and manage your heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10757722 on NIH RePORTER |
What this research studies
This research investigates how mechanical properties of coronary artery lesions can help predict their risk of rupture and progression. By focusing on factors beyond traditional imaging techniques, the study aims to identify which lesions are more likely to cause acute coronary syndromes. Patients will be evaluated through prospective studies that track the natural history of coronary atherosclerosis, using innovative biomechanical metrics to enhance risk stratification. The goal is to improve the accuracy of predicting which lesions may lead to serious cardiovascular events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with coronary artery disease or those at risk for acute coronary syndromes.
Not a fit: Patients without coronary artery disease or those who do not have risk factors for acute coronary syndromes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of high-risk coronary lesions, potentially preventing acute coronary events in patients.
How similar studies have performed: Other research has shown promise in using biomechanical metrics for risk stratification in cardiovascular conditions, indicating that this approach may yield significant insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Hsu, Edward W — University of Utah
- Study coordinator: Hsu, Edward W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.