Understanding the proteins involved in Polycystic Kidney Disease
Official title: Structural Mechanisms of Polycystic Kidney Disease Proteins
Funded at University of Utah · NIH-11141713 · Data updated 2026-11-12
This study is looking at how certain proteins important for kidney health work and fit together, which could help us understand and treat autosomal dominant polycystic kidney disease (ADPKD) better, so patients like you can have more options for managing the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 22, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $666,838 |
| NIH project number | 5R01DK139541-02 |
| Project ID | NIH-11141713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
✕Less likely to help
Patients with other forms of kidney disease unrelated to polycystin proteins may not receive benefit from this research.
What this research studies
This research investigates the structural mechanisms of polycystin proteins, which are crucial for kidney function and are implicated in autosomal dominant polycystic kidney disease (ADPKD). By examining how these proteins assemble and function, the research aims to uncover their roles in kidney architecture and disease progression. The study utilizes advanced biochemical assays and cellular models to analyze the interactions and signaling pathways of these proteins. Patients with ADPKD may benefit from insights gained into the disease mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with autosomal dominant polycystic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding polycystin proteins, but this study aims to explore novel aspects of their structure and function.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Cao, Erhu — University of Utah
- Study coordinator: Cao, Erhu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.