Understanding the proteins in cilia and their roles in health and disease
Official title: Defining the ciliary proteomes in vivo
Funded at University of Alabama at Birmingham · NIH-11112660 · Data updated 2026-11-12
This study is looking at tiny structures in our cells called cilia, which are important for our health, to understand how changes in their proteins might lead to diseases like blindness, obesity, and brain disorders, with the hope of finding better treatments for these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $222,750 |
| NIH project number | 1R21OD038399-01 |
| Project ID | NIH-11112660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known ciliopathies or related genetic conditions affecting ciliary function.
✕Less likely to help
Patients without any genetic predisposition to ciliopathies or those with unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the proteins found in cilia, which are essential structures in our cells that play a critical role in development and function. By examining how these proteins change in different cell types and conditions, the study aims to uncover the mechanisms behind various diseases linked to ciliary dysfunction, known as ciliopathies. The research utilizes advanced techniques to analyze the ciliary proteome in mouse models, providing insights into how genetic mutations affect ciliary function and contribute to health issues. This knowledge could lead to better understanding and potential treatments for conditions like blindness, obesity, and neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for a range of diseases associated with ciliary dysfunction.
How similar studies have gone: While research on ciliary function is ongoing, this specific approach to mapping the ciliary proteome is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Yoder, Bradley K. — University of Alabama at Birmingham
- Study coordinator: Yoder, Bradley K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.