Understanding the progression and impact of autoimmune pulmonary alveolar proteinosis.
Retrospective Autoimmune PAP Natural History and Patient-Reported Outcomes Study
This study is looking into a rare lung condition called autoimmune pulmonary alveolar proteinosis (aPAP) to better understand how it affects patients over time, what treatments they might need, and how it impacts their breathing, all while creating new ways to track changes in their health based on their own experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10571074 on NIH RePORTER |
What this research studies
This research investigates autoimmune pulmonary alveolar proteinosis (aPAP), a rare lung disorder, by analyzing data from the US National PAP Registry. It aims to define the natural history of aPAP, including how the disease progresses, the treatment needs of patients, and the impact on lung function. Additionally, the study will develop and validate new tools to measure changes in disease severity based on patient-reported outcomes. This approach will help provide a clearer understanding of the condition and improve future treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune pulmonary alveolar proteinosis.
Not a fit: Patients with other forms of pulmonary diseases unrelated to aPAP may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies and treatment options for patients with aPAP.
How similar studies have performed: While there have been advances in understanding aPAP, this research is novel as it aims to establish a comprehensive natural history and validated outcome measures for the condition.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Trapnell, Bruce C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Trapnell, Bruce C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.