Understanding the pituitary gland's role in health and disease
Integrated systems biology of the pituitary
This research aims to understand how the pituitary gland works and changes during normal body functions and in conditions like hypothyroidism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11133571 on NIH RePORTER |
What this research studies
Our bodies rely on the pituitary gland to control many hormone systems, and this project uses advanced techniques to look closely at individual cells within the pituitary. We are developing new ways to examine the genetic and epigenetic information in these cells, even down to how genes are 'read' differently. This helps us see how pituitary cells can change and adapt, which is important for both normal body function and when diseases develop. By understanding these changes, we hope to uncover new insights into conditions affecting the pituitary.
Who could benefit from this research
Good fit: This foundational research is relevant to adult patients with conditions affecting the pituitary gland, such as primary hypothyroidism.
Not a fit: Patients without pituitary-related conditions or those seeking immediate clinical interventions may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of pituitary-related diseases, potentially paving the way for new diagnostic tools or treatments.
How similar studies have performed: Previous work has successfully optimized methods for generating high-quality single-cell data, providing a strong foundation for this new exploration into pituitary cell plasticity.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Sealfon, Stuart C. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sealfon, Stuart C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.