Understanding the pathways involved in Autosomal Dominant Polycystic Kidney Disease
In vivo Pathway Discovery in Autosomal Dominant Polycystic Kidney Disease
This study is looking at how certain proteins and processes in the body might affect the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD), and it invites patients to help by sharing samples or information to find new ways to treat this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10634757 on NIH RePORTER |
What this research studies
This research investigates Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic condition that leads to the formation of large cysts in the kidneys, causing progressive loss of kidney function. The study focuses on the role of specific proteins and metabolic pathways that may contribute to the disease's progression. By examining how these pathways interact and affect kidney cells, researchers aim to uncover potential new targets for treatment. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those experiencing symptoms or at risk of kidney function decline.
Not a fit: Patients without a diagnosis of Autosomal Dominant Polycystic Kidney Disease or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent kidney damage in patients with ADPKD.
How similar studies have performed: Previous research has shown promise in understanding metabolic pathways in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Somlo, Stefan — Yale University
- Study coordinator: Somlo, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.