Understanding the origins of lung adenocarcinoma
Official title: Elucidating the Cellular Origins of lung adenocarcinoma
Funded at Beckman Research Institute/city of Hope · NIH-10886130 · Data updated 2026-11-12
This study is looking into how certain lung cells might lead to lung adenocarcinoma, the most common kind of lung cancer, and it aims to find out how these changes can differ based on factors like age and ethnicity, which could help create better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | July 11, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $432,749 |
| NIH project number | 5R01CA262258-03 |
| Project ID | NIH-10886130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with lung adenocarcinoma, particularly those with varying histologic subtypes.
✕Less likely to help
Patients with other types of lung cancer or those without a lung cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the cellular origins of lung adenocarcinoma (LUAD), the most common type of lung cancer. It focuses on identifying which types of lung cells contribute to the development of LUAD, particularly examining the roles of alveolar epithelial cells. By utilizing advanced mouse models, the study aims to uncover the genetic and molecular changes that lead to cancer formation, which may vary based on patient demographics such as age and ethnicity. The findings could help in developing targeted therapies and improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung adenocarcinoma by identifying specific cellular origins and mechanisms of the disease.
How similar studies have gone: Previous research has shown promising results in understanding cancer origins through cellular analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Marconett, Crystal Nicole — Beckman Research Institute/city of Hope
- Study coordinator: Marconett, Crystal Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.