Understanding the origin of anti-dsDNA antibodies in lupus
Official title: The antigenic origin of anti-dsDNA antibodies in SLE
Funded at Johns Hopkins University · NIH-11017818 · Data updated 2026-11-12
This study is looking into how certain antibodies related to lupus are formed, which could help us understand the disease better and find new ways to treat it, so patients can feel more informed and hopeful about their condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $198,547 |
| NIH project number | 5R21AI183329-02 |
| Project ID | NIH-11017818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus who have detectable levels of anti-dsDNA antibodies.
✕Less likely to help
Patients without systemic lupus erythematosus or those who do not produce anti-dsDNA antibodies may not benefit from this research.
What this research studies
This research investigates the origins of anti-dsDNA antibodies, which are crucial for diagnosing and monitoring systemic lupus erythematosus (SLE). The study aims to explore a new hypothesis that these antibodies may arise from germline precursors that initially target a protein self-antigen, with subsequent cross-reactivity to dsDNA. By examining the mechanisms behind this antibody formation, the research seeks to uncover important insights into the pathogenesis of SLE. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment strategies for patients with systemic lupus erythematosus.
How similar studies have gone: Previous research has established a strong link between anti-dsDNA antibodies and SLE, but this specific approach exploring cross-reactivity is novel and has not been extensively tested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Andrade, Felipe — Johns Hopkins University
- Study coordinator: Andrade, Felipe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.