Understanding the nerve structure of the jaw joint in humans and mice
Neural Architecture of the Murine and Human Temporomandibular Joint
This study is looking at the nerves in the jaw joint to figure out why some people have ongoing pain and problems with their jaw, which could help create better treatments for those dealing with jaw pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10608491 on NIH RePORTER |
What this research studies
This research investigates the complex nerve architecture of the temporomandibular joint (TMJ) to better understand the causes of temporomandibular disorders (TMDs), which are a common source of chronic facial pain. By using advanced imaging techniques and molecular tracing methods, the research aims to map the sensory nerves in both human and mouse TMJ tissues. The findings could lead to new insights into how these nerves contribute to pain and dysfunction in the jaw, ultimately guiding the development of targeted treatments for TMDs.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who experience symptoms of temporomandibular disorders.
Not a fit: Patients who do not have temporomandibular disorders or related chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from chronic jaw pain and related disorders.
How similar studies have performed: Previous research has shown promise in mapping neural structures in other joints, suggesting that this approach could yield valuable insights for TMDs as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Donnelly, Christopher Ryan — Duke University
- Study coordinator: Donnelly, Christopher Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.