Understanding the nerve functions related to jaw joint pain
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male female and aged mice primates and humans with and without TMJ disorders (TMJD)
This study is looking at the nerve cells connected to the jaw joint to better understand the pain people feel with TMJ disorders, and it hopes to find new ways to help treat that pain for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10608279 on NIH RePORTER |
What this research studies
This research investigates the types and functions of nerve cells that connect to the temporomandibular joint (TMJ) tissues, which are crucial for understanding pain associated with TMJ disorders. By studying these nerve cells in various subjects, including mice, primates, and humans, the research aims to identify how these nerves behave and change in response to TMJ pain. The project will utilize advanced techniques to map the distribution and characteristics of these nerves, potentially leading to new therapeutic targets for treating TMJ disorders. Patients may benefit from insights gained that could inform future treatment options for TMJ pain.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing temporomandibular joint pain, regardless of age or gender.
Not a fit: Patients without any symptoms of temporomandibular joint disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from temporomandibular joint disorders.
How similar studies have performed: Previous research has shown promising results in understanding nerve functions related to pain, suggesting that this approach may yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Akopian, Armen N — University of Texas Hlth Science Center
- Study coordinator: Akopian, Armen N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.