Understanding the nerve connections and types of cells in the knee joint
Neuronal anatomy, connectivity, and phenotypic innervation of the knee joint
This study is looking at the nerves in the knee to understand how pain works, which could help create better treatments for people with knee pain, like those with osteoarthritis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10608851 on NIH RePORTER |
What this research studies
This research investigates the complex network of nerves in the knee joint to better understand how pain is perceived. By utilizing advanced technologies such as viral vectors and 3D visualization techniques, the study aims to map out the types and distribution of neurons and their connections in joint tissues. It also employs single-cell RNA sequencing to analyze the molecular characteristics of these cells, which could lead to more targeted therapies for conditions like osteoarthritis. Patients may benefit from insights gained about pain mechanisms and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from knee joint pain, particularly those with osteoarthritis.
Not a fit: Patients with knee joint issues unrelated to nerve function or those who do not experience pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies and targeted therapies for knee joint conditions.
How similar studies have performed: Other research has shown promise in using advanced imaging and molecular techniques to understand pain pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Brendan — Baylor College of Medicine
- Study coordinator: Lee, Brendan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.