Understanding the molecular changes in the brain after traumatic injury
Spatiotemporal Molecular Substrates of TBI at Single Cell Resolution
This study is looking at how brain cells change after a traumatic brain injury to better understand how it might lead to other issues like chronic traumatic encephalopathy and PTSD, so we can help people who have experienced such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10817748 on NIH RePORTER |
What this research studies
This research investigates the complex changes in brain cells following traumatic brain injury (TBI) by examining individual cells at a high resolution. Using advanced techniques like single cell RNA sequencing, the study aims to identify specific molecular pathways and metabolic changes that occur in the brain after injury. By understanding these changes, researchers hope to uncover how TBI can lead to other disorders such as chronic traumatic encephalopathy and posttraumatic stress disorder. The approach focuses on the dynamic interactions between different cell types and their roles in the progression of TBI-related pathologies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are experiencing cognitive or emotional difficulties.
Not a fit: Patients who have not experienced a traumatic brain injury or those with pre-existing neurological conditions unrelated to TBI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from the long-term effects of traumatic brain injuries.
How similar studies have performed: Other research has shown promise in using single cell analysis to understand brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yang, Xia — University of California Los Angeles
- Study coordinator: Yang, Xia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.